Telomere Length and Frailty: The Helsinki Birth Cohort Study
نویسندگان
چکیده
منابع مشابه
Exposure to Persistent Organic Pollutants Predicts Telomere Length in Older Age: Results from the Helsinki Birth Cohort Study
As the population ages, the occurrence of chronic pathologies becomes more common. Leukocyte telomere shortening associates to ageing and age-related diseases. Recent studies suggest that environmental chemicals can affect telomere length. Persistent organic pollutants (POPs) are most relevant, since they are ingested with foods, and accumulate in the body for a long time. This longitudinal stu...
متن کاملDevelopmental Origins of Physical Fitness: The Helsinki Birth Cohort Study
BACKGROUND Cardiorespiratory fitness (CRF) is a major factor influencing health and disease outcomes including all-cause mortality and cardiovascular disease. Importantly CRF is also modifiable and could therefore have a major public health impact. Early life exposures play a major role in chronic disease development. Our aim was to explore the potential prenatal and childhood origins of CRF in...
متن کاملAdiposity, telomere length and telomere attrition in midlife: the 1946 British Birth Cohort.
Background Obesity has been linked with shorter telomere length, both of which have been implicated in ageing, but the impact of early life adiposity on telomere length is unclear. Methods We included 2,479 participants from the MRC National Survey of Health and Development with measurements of body mass index (BMI), waist and hip circumference and leukocyte telomere length (LTL) at age 53, o...
متن کاملPrenatal undernutrition and leukocyte telomere length in late adulthood: the Dutch famine birth cohort study.
BACKGROUND Energy restriction in prenatal life has detrimental effects on later life health and longevity. Studies in rats have shown that the shortening of telomeres in key tissues plays an important role in this association. OBJECTIVE The aim of the current study was to investigate leukocyte telomere length in relation to prenatal famine exposure. DESIGN The Dutch famine birth cohort cons...
متن کاملLate-preterm birth and lifetime socioeconomic attainments: the Helsinki birth cohort study.
OBJECTIVE We examined if those born late-preterm (at 34 to 36 weeks of gestation) differed from those born at term in their maximum attained lifetime socioeconomic position (SEP) across the adult years up to 56 to 66 years, and in intergenerational social mobility from childhood parental SEP to own attained SEP. METHODS Participants were 8993 Finnish men and women of the Helsinki Birth Cohort...
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ژورنال
عنوان ژورنال: Journal of the American Medical Directors Association
سال: 2018
ISSN: 1525-8610
DOI: 10.1016/j.jamda.2018.05.011